Those
who think that if a little vitamin C is good, more must be better
should think again, says a team of British researchers, who found that a
supplement of 500 milligrams a day could damage people's genes.
Many
Americans take that much, or more, in hopes of preventing colds and
reaping the widely celebrated antioxidant benefits of vitamin C.
Antioxidants, which block cellular and molecular damage caused by the
highly reactive molecules called free radicals, are believed to protect
against heart disease, cancer, eye disorders like cataracts and macular
degeneration, and other chronic health problems.
But the British
researchers, chemical pathologists at the University of Leicester, found
in a six-week study of 30 healthy men and women that a daily
500-milligram supplement of vitamin C had pro-oxidant as well as
antioxidant effects on the genetic material DNA. The researchers found
that at the 500-milligram level, vitamin C promoted genetic damage by
free radicals to a part of the DNA, the adenine bases, that had not
previously been measured in studies of the vitamin's oxidative
properties.